Sepsis and Appendicitis

It used to be that almost everyone had their appendix removed at some point during their childhood. Now however, the surgery isn’t as common and many adults still have their appendix.

Appendicitis is the inflammation of the appendix, a small organ attached to the large intestine. In the past, doctors thought that the appendix didn’t have any function, but now they aren’t sure. The appendix is not an organ that we must have though, so if it becomes infected, it is removed by surgery called an appendectomy.

Your appendix can become inflamed for a number of reasons. It can be blocked by mucus, stool (bowel movement), or lymphatic tissue, part of the lymphatic system that helps fight infection. The normally harmless bacteria in the appendix then begins to attack the appendix walls, resulting in inflammation and infection. If left untreated, this can rupture the appendix wall, causing the infection to spread in the abdomen and, possibly, throughout the body, resulting in sepsis or severe sepsis.

Sometimes called blood poisoning, sepsis is the body's often deadly response to infection or injury. Sepsis kills and disables millions and requires early suspicion and rapid treatment for survival.

Worldwide, one-third of people who develop sepsis die (What is the prognosis (outcome) with sepsis?). Many who do survive are left with organ dysfunction (don’t work properly) and/or amputations.

Sepsis may also occur as a complication of the surgery in general (Sepsis and Surgery).